Research Technician II Formulation

Site: Mass General Brigham Incorporated

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

GENERAL SUMMARY / OVERVIEW:

The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system. The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients. The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies.

We are seeking a motivated and skilled Technician to join our RNA Therapeutics Core (RTC) team and participate in the development of novel RNA-based medicines and technologies. With guidance from senior scientific staff, the candidate who fills this role will produce and analyze high quality lipid nanoparticle formulations of RNA for experimental applications and external parties, and administer formulated RNA to mice via different injection routes.

The successful candidate will have experience working in a research laboratory environment and be proficient in standard mouse handling techniques such as tail vein injections, subcutaneous injections, and sample collection, as well as lipid nanoparticle formulation. They would preferably have hands-on LNP process development experience, be detail-oriented and organized, and eager to work in a team environment.

Qualifications

• Bachelor's degree in life sciences, biochemistry, chemistry, or chemical engineering with at least 1-2 years of experience in a laboratory setting

• Good organizational skills, detail oriented

• Reproducibility of work with accuracy

• Sound degree of computer literacy

• Ability to methodically record data

• Good interpersonal and communication skills

• Ability to demonstrate professionalism

• Dedication to excellence

PREFERRED COMPETENCIES:

• Experience working with mice

• Experience formulating and analyzing lipid nanoparticles

PRINCIPAL DUTIES AND RESPONSIBILITIES:

• Perform a variety of routine procedures following established methodologies including lipid nanoparticle formulation, flash freezing, and dialysis

• Perform analytical techniques such as dynamic light scattering and concentration measurements via nucleic acid entrapment assay and record quality metrics, with a strong focus on accuracy and reproducibility in work

• Perform routine mouse handling procedures including tail vein injection, anesthetization, tail and cheek bleeds, live imaging, and wellness monitoring

• Operate laboratory equipment, instruments and robotics to perform repetitive laboratory techniques; learn how to use new instruments

• Use universal safety precautions and proper personal protective equipment to protect self and co-workers from biohazardous materials; complete requisite trainings as appropriate

• Participate in lab meetings and generate ideas for improving efficiency and productivity in the labs operations

• Communicate effectively with the team, discuss progress, and share data with supervisors

• All other duties as assigned

Additional Job Details (if applicable)

Remote Type

Hybrid

Work Location

65 Landsdowne Street

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

EEO Statement:

Mass General Brigham Incorporated is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veterans Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at .... Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.